Amyloidosis - Two Unusual Presentations

Najeeba Riyaz, Bindu V, Naazneen Nasir, Deepthi N S


Amyloidosis is a disease produced by the extra cellular deposition of heterogenic, misfolded proteins, amyloid fibrils, in various tissues. It usually manifests as a systemic disease characterized by multiple organ and tissue involvement. Rarely amyloidosis remains restricted to a single tissue or organ. We report two cases of amyloidosis: a 63 year old lady with primary localized cutaneous amyloidosis (PLCA) presenting with xanthomatous lesions over the trunk and a 61year old man who had evidence of renal involvement in addition to the cutaneous lesions.

Key words:  Amyloidosis, Xanthomatous lesions, Renal involvement

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Breathnach SM. Amyloid and Amyloidosis. J Am Acad Dermatol. 1988;18:1–16.

Wong CK, Breathnach SM. Cutaneous Amyloidosis. Clin Dermatol. 1990;8(2):108–11

Bridoux F. Localized amyloidosis: Clinical features and outcome in 203cases. Paper presented at the X International Symposium on Amyloid and Amyloidosis, Tours, France, 2004. Abstract No. O50

Brownstein MH, Helwig EB. The cutaneous amyloidoses. Localized forms. Arch Dermatol. 1970;102(1):8–19.

Breathnach SM. Metabolic and Nutritional Disorders. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook's Textbook of Dermatology. 7 th ed. Oxford: Blackwell publishing; 2004. p. 57.36-57.51.

Milliken JA. Primary systemic amyloidosis. Canad Med Assoc J 1955;73: 458- 62.

AL Amyloidosis. Desport E, Bridoux F, Sirac C, Delbes S, Bender S, Fernandes B, et al. Orphanet J Rare Dis 2012; 7:54.

Kyle RA, Gertz MA. Primary systemic amyloidosis: clinical and laboratory features

in 474 cases. Semin Hematol 1995; 32: 45–59.

Kaltoft B, Schmidt G, Lauritzen AF, Gimsing P. Primary localized cutaneous amyloidosis- systematic review. Dan Med J 2013; 60: A4727.


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